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The Human Serum Metabolome

Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the metabolomics community to develop centralized metabolite reference resources for certain clinically important biofluids, such as cerebrospinal fluid, urine and blood. As part of an ongoing effort to systematically characterize the human metabolome through the Human Metabolome Project, we have undertaken the task of characterizing the human serum metabolome. In doing so, we have combined targeted and non-targeted NMR, GC-MS and LC-MS methods with computer-aided literature mining to identify and quantify a comprehensive, if not absolutely complete, set of metabolites commonly detected and quantified (with today's technology) in the human serum metabolome. Our use of multiple metabolomics platforms and technologies allowed us to substantially enhance the level of metabolome coverage while critically assessing the relative strengths and weaknesses of these platforms or technologies. Tables containing the complete set of 4229 confirmed and highly probable human serum compounds, their concentrations, related literature references and links to their known disease associations are freely available at http://www.serummetabolome.ca.

Citation

N. Psychogios, D. Hau, J. Peng, A. Guo, R. Mandal, S. Bouatra, I. Sinelnikov, R. Krishnamurthy, R. Eisner, B. Gautam, N. Young, J. Xia, C. Knox, E. Dong, P. Huang, Z. Hollander, T. Pedersen, S. Smith, F. Bamforth, R. Greiner, B. McManus, J. Newman, T. Goodfriend, D. Wishart. "The Human Serum Metabolome". PLoS One, 6(2), March 2011.

Keywords: bioinformics, medical informatics, serum, metabolomics
Category: In Journal
Web Links: DOI

BibTeX

@article{Psychogios+al:PLoSONE11,
  author = {Nikolaos Psychogios and David D. Hau and Jun Peng and An Chi Guo
    and Rupasri Mandal and Souhaila Bouatra and Igor Sinelnikov and Ramanarayan
    Krishnamurthy and Roman Eisner and Bijaya Gautam and Nelson Young and
    Jianguo Xia and Craig Knox and Edison Dong and Paul Huang and Zsuzsanna
    Hollander and Theresa L. Pedersen and Steven R. Smith and Fiona Bamforth
    and Russ Greiner and Bruce McManus and John W. Newman and Theodore
    Goodfriend and David S. Wishart},
  title = {The Human Serum Metabolome},
  Volume = "6",
  Number = "2",
  journal = {PLoS One},
  year = 2011,
}

Last Updated: September 21, 2012
Submitted by Russ Greiner

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