Not Logged In

Time-domain analysis of heart sound intensity in children with and without pulmonary artery hypertension: a pilot study using a digital stethoscope

We studied digital stethoscope recordings in children undergoing simultaneous catheterization of the pulmonary artery (PA) to determine whether time-domain analysis of heart sound intensity would aid in the diagnosis of PA hypertension (PAH). Heart sounds were recorded and stored in .wav mono audio format. We performed recordings for 20 seconds with sampling frequencies of 4,000 Hz at the second left intercostal space and the cardiac apex. We used programs written in the MATLAB 2010b environment to analyze signals. We annotated events representing the first (S1) and second (S2) heart sounds and the aortic (A2) and pulmonary (P2) components of S2. We calculated the intensity (I) of the extracted event area (x) as An external file that holds a picture, illustration, etc. Object name is PulmCirc-004-685.e001.jpg, where n is the total number of heart sound samples in the extracted event and k is A2, P2, S1, or S2. We defined PAH as mean PA pressure (mPAp) of at least 25 mmHg with PA wedge pressure of less than 15 mmHg. We studied 22 subjects (median age: 6 years [range: 0.25–19 years], 13 female), 11 with PAH (median mPAp: 55 mmHg [range: 25–97 mmHg]) and 11 without PAH (median mPAp: 15 mmHg [range: 8–24 mmHg]). The P2∶A2 (P = .0001) and P2∶S2 (P = .0001) intensity ratios were significantly different between subjects with and those without PAH. There was a linear correlation (r > 0.7) between the P2∶S2 and P2∶A2 intensity ratios and mPAp. We found that the P2∶A2 and P2∶S2 intensity ratios discriminated between children with and those without PAH. These findings may be useful for developing an acoustic device to diagnose PAH.

Citation

M. Elgendi, P. Bobhate, S. Jain, J. Rutledge, J. Coe, R. Zemp, D. Schuurmans, I. Adatia. "Time-domain analysis of heart sound intensity in children with and without pulmonary artery hypertension: a pilot study using a digital stethoscope". Pulmonary Circulation, 4(4), pp Elgendi, M., Bobhate, P., Jain, S., Rutledge, J., Coe, J. Y., Zemp, R., Schuurmans, D., & Adatia, I. (2014). Time-domain analysis of heart sound intensity in children with and without pulmonary artery hypertension: a pilot study using a digital steth, December 2014.

Keywords: auscultation, second heart sound, phonocardiography, machine learning
Category: In Journal
Web Links: PMC
  DOI

BibTeX

@article{Elgendi+al:14,
  author = {Mohamed Elgendi and Prashant Bobhate and Shreepal Jain and Jennifer
    Rutledge and James Y. Coe and Roger Zemp and Dale Schuurmans and Ian
    Adatia},
  title = {Time-domain analysis of heart sound intensity in children with and
    without pulmonary artery hypertension: a pilot study using a digital
    stethoscope},
  Volume = "4",
  Number = "4",
  Pages = {Elgendi, M., Bobhate, P., Jain, S., Rutledge, J., Coe, J. Y., Zemp,
    R., Schuurmans, D., & Adatia, I. (2014). Time-domain analysis of heart
    sound intensity in children with and without pulmonary artery hypertension:
    a pilot study using a digital steth},
  journal = {Pulmonary Circulation},
  year = 2014,
}

Last Updated: March 19, 2020
Submitted by Sabina P

University of Alberta Logo AICML Logo